The Korea Mouse Phenotyping Center (KMPC) was established by the South Korean Ministry of Science and ICT in 2013 with the aim of developing genetically engineered mice (GEM), analyzing mouse phenotypes, and sharing mouse resource information. KMPC created the Mouse One Portal (MOP) in 2016, which is a one-stop online platform for mouse resources, with a focus on ease of use and a simple process. Through MOP, researchers are able to select and submit applications for various phenotype services in following specialties such as metabolism and exercise, sensory, in vivo molecular imaging, pathology, primary and secondary, cardiovascular, and immunophenotyping and resource services (banking, rederivation, health monitoring, and genetic monitoring) with ease. MOP is also a user-friendly platform for finding GEM information of domestic and international mouse communities at a glance, ordering bespoke mouse production, and sharing mouse resources with others.
Drawing upon KMPC’s expertise on mouse resources and relevant data management, the South Korean government designated KMPC as the principal organization for preclinical trials using mice and hamsters in 2020 as well as for a model animal bioresource cluster in 2021.
For more efficient and reliable preclinical trials, KMPC has established a research alliance by linking several BSL-3 facilities in its network and has created standardized protocol guidelines. KMPC has also created a laboratory information management system (LIMS) to store large-scale data; this database will enable Korean researchers to handle mutant viruses and disease X promptly and precisely in the future.
Diverse model animal resources play a vital role in improving research competence in biomedicine. To foster bioresources and accelerate the growth of bioresearch, the South Korean government has restructured 274 formerly scattered bioresource banks into 14 bioresource clusters, including the model animal cluster for which KMPC was designated the principal organization. Thanks to its rich experience with MOP, KMPC has been making efforts to develop the Korean Animal Model Archive (KAMA), an integrated system of model animal resource information.
KMPC has consistently contributed to the global leadership of research communities on mouse models and is actively involved in the International Mouse Phenotyping Consortium (IMPC) as the only institutional member in South Korea, the Asian Mouse Mutagenesis Resource Association (AMMRA), and Global Mouse Models for COVID-19 Consortium (GMMCC). KMPC plays a crucial role in building a fundamental infrastructure for mouse research, thereby contributing to advancing biomedical research in the world.
For more detailed information on what KMPC has been doing, please see below:
•Mouse model database is a bank of potential: https://www.nature.com/articles/d42473-020-00131-x (About KMPC in general)
•Mouse phenotyping center: A pillar of pandemic research https://www.nature.com/articles/d42473-022-00013-4 (About setup of the infrastructure for the COVID-19 preclinical research)
•A wealth of bioresources: https://www.nature.com/articles/d42473-021-00569-7 (About Model Animal Bioresources Cluster)
•Asian Mouse Mutagenesis Resource Association (AMMRA): Mouse genetics and laboratory animal resources in the Asia Pacific: https://doi.org/10.1007/s00335-021-09912-1